Eye disorders and Zebrafish


Video links : human eye disorders

Headaches May Signal Eye Disease: People who get migraines and other headaches are more likely to have retinoplathy, an eye disease that could cause blindness, a new study finds.

Macular Degeneration Research: Macular degeneration research and the artificial retina. Vision loss from retinal diseases including macular degeneration and retinitis pigmentosa may be treated in the future with an artificial or bionic eye.

Bionic Eye: from HumbleLife

Macular Degeneration - New Treatments: Dr. Esther Bowie discusses new treatments for Macular Degeneration.

Genentech Avastin - Wet Macular Degeneration: Leading retinal specialist Mike Lavin - "Doctors cannot tell the difference between Lucentis treated and Avastin Treated Eyes - in terms of vision outcomes and adverse effects". Check with your consultant for the latest information about risks and outcomes.


Video links : the zebrafish model system

Zebrafish Heart Regeneration: When the zebrafish heart is damaged, the wound site is rapidly sealed with a fibrin clot that stems bleeding within seconds. Following clot formation, the tissue that surrounds the heart muscle—the epicardium—gradually covers the fibrin clot via migration and cell division. Over the next few months, new cardiac muscle is produced and replaces the clot. Growth factors, like FGF1, produced by the new heart tissue, signals the cells of the epicardial layer to migrate into the heart and form new blood vessels, to provide essential blood flow to the regenerating tissue. Over time, the wounded zebrafish heart returns to nearly its original shape, size, and pumping ability.

Zebrafish development timelapse: This is a timelapse recording of about 18 hours of embryonic development of the zebrafish, Danio rerio

Early Zebrafish Development: Zebrafish development. Ref.: Molecular Biology of the Cell, 4th Edition, by Alerts, Johnson, Lewis. Raff, Roberts, Walter

Movie reveals how nerves get their insulating layer: Vanderbilt researchers have produced the first time-lapse movies of the process that wraps an outer, insulating layer of myelin around the nerve fibers as the spinal cord develops in vertebrates. The movies were taken of the process in living zebrafish embryos. The researchers discovered that the initial stage in this process is surprisingly dynamic. Special glial cells, called oligodendrocyte progenitors (OPCs), spread out along new axons and continually jockey for position until they are uniformly spaced along the length of the spinal cord. Two of OPCs have been colored green to make them easier to follow. When they are properly spaced, a fraction of these OPCs transform into oligodendrocytes which extrude myelin membranes that wrap around the axons.

Zebrafish Research: Jessica Perry, a student at OSU, is doing student research on Zebra Fish. The regenerative features of the fish allow for medical advancements in skin regrowth as well as other agricultural benefits.

Annotated zebrafish development timelapse: This is a timelapse recording of about 18 hours of embryonic development of the zebrafish, Danio rerio, with some annotation added


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